
Amoxicillin shows similar efficacy to amoxicillin-clavulanate for acute sinusitis, with fewer adverse events, supporting first-line use.

Timothy J. Savage, MD, MPH, MSc, is an instructor in medicine at Harvard Medical School, an investigator in the Department of Medicine at Mass General Brigham, and an assistant in pediatrics in the Division of Infectious Diseases at Boston Children’s Hospital.

Amoxicillin shows similar efficacy to amoxicillin-clavulanate for acute sinusitis, with fewer adverse events, supporting first-line use.