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Friday's 5 Quotes for Primary Care 3-10-2023


Each of the quotes that follow is taken from a study reviewed on Patient Care® during the past week and was chosen for the research team’s passion about the clinical implications of their findings and for their potential impact on primary care practice.

“Among the participants on an low carbohydrate, high fat (LCHF) diet, we found that those with the highest levels of LDL cholesterol were at the highest risk for a cardiovascular event,” Iatan said. “Our findings suggest that people who are considering going on an LCHF diet should be aware that doing so could lead to an increase in their levels of LDL cholesterol. Before starting this dietary pattern, they should consult a health care provider.”

“Although the current data must not be construed to diminish the crucial role of adjunctive lipid lowering beyond statins for patients with persistent or refractory hypercholesterolemia, they do suggest that targeting LDLC alone is unlikely to completely reduce atherosclerotic risk...We believe that combined use of aggressive lipid-lowering and anti-inflammatory therapies might become standard of care for atherosclerotic disease in the future.”

Residual Inflammation in Statin-treated Patients Linked to Greater Risk for MACE, Mortality vs Residual Cholesterol

“A coordinated multifaceted intervention focused on collaborative care and reducing barriers to optimal pharmacotherapy increased the likelihood by 4-fold that patients with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD) would be prescribed 3 classes of guideline-directed medical therapies (GDMT) when compared to usual care.”

Likelihood of Optimal GDMT for Patients with T2D, ASCVD Increased with Multifaceted Clinic Intervention

“Statin intolerance remains a vexing clinical problem that can prevent patients who are guideline-eligible for statin treatment from reaching LDL cholesterol levels associated with clinical benefits. Accordingly, alternative nonstatin therapies are needed to manage the LDL cholesterol level in these patients. This is the first study that directly addressed the problem of statin-intolerant patients.”

"Daily users of marijuana were found to be 34% more likely to have coronary artery disease (CAD) than never-users in a Mendelian randomization study. 'We found that cannabis use is linked to CAD, and there seems to be a dose-response relationship in that more frequent cannabis use is associated with a higher risk of CAD. In terms of the public health message, it shows that there are probably certain harms of cannabis use that weren’t recognized before, and people should take that into account.'”

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