If RLS Is Suspected, What Test Would You Order Next?

A 32-year-old woman who works as an attorney complains that she has had difficulty in falling and staying asleep for the past 2 years. She describes “tension” in her arms, abdominal area, and legs throughout the day; the sensation wakes her from sleep at night and she must get out of bed and walk for partial relief. She denies any sensory abnormalities.

As you strongly suspect RLS, what would be the single most appropriate test to perform next?

A. CBC count
B. Serum ferritin level
C. Nerve conduction study
D. Polysomnography
E. Liver function studies

Please consider a selection, then click here for answer and discussion.