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Keratoderma
This is a classic keratoderma, which can be due to a variety of congenital defects in keratinization or acquired in association with disease states. Retinoids, systemic and topical, are the treatments of choice.
A 36-year-old man complained about his inability to walk because of extremely thickened soles. This condition had been present, to a variable degree, his entire life.
Key points: Physical examination disclosed massive hyperkeratosis that affected both soles. Some tender and spontaneous painful fissuring was present. This is a classic keratoderma, which can be due to a variety of congenital defects in keratinization or acquired later in life in association with disease states (eg, Reiter syndrome, psoriasis, pityriasis rubra pilaris).
Treatment: Systemic and/or concomitant topical retinoids are the treatments of choice. This patient was treated with acitretin (50 mg/d orally) and tazarotene (0.05% cream, applied twice daily), with significant improvement.
Note: Adjunctive therapy may consist of application of humectant and emollient-containing moisturizers. Such moisturizers might include lactic acid, urea, petrolatum, and mineral oil.
Biden Administration Announces First 10 Prescription Drugs Slated for Price Negotiations
August 29th 2023The first 10 drugs identified for negotiations under the Inflation Reduction Act include several well advertised agents indicated to treat diabetes, heart failure, and other chronic diseases.
