Statin-Drug Interactions: Update on the Most Common and Clinically Significant

September 15, 2005
Timothy H. Self, PharmD

,
Bob L. Lobo, PharmD

,
Chris Sands, MD

Statins (HMG-CoA reductase inhibitors) are the most effective drugs in the management of elevated low-density lipoprotein cholesterol (LDL-C) levels. Recent large clinical trials continue to demonstrate the remarkable efficacy of these agents, including improved outcomes.

Statins (HMG-CoA reductase inhibitors) are the most effective drugs in the management of elevated low-density lipoprotein cholesterol (LDL-C) levels.1 Recent large clinical trials continue to demonstrate the remarkable efficacy of these agents, including improved outcomes.2,3

Our purpose here is to summarize some clinically relevant examples of statin-drug interactions. Appropriate management of these interactions can both minimize risks and ensure effective statin doses.

The Table lists several examples of statin-drug interactions. Because of the limited scope of this review, the emphasis is on atorvastatin and simvastatin. These statins were selected because they were used in several landmark clinical trials, are commonly prescribed, and are on many formularies.

Table - Examples of statin-drug interactions: focus on atorvastatin and simvastatin*

DrugComment

Amiodarone14

Limit simvastatin dosage to