The primary male sex hormone connects with a variety of health factors, and therapy could have positive effects. A quick look at 6 new studies.
Testosterone Lowers Cardiovascular Risks. Testosterone replacement therapy (TRT) is not linked with increased cardiovascular (CV) risks in men with androgen deficiency. In this study, the primary outcome was a composite of CV end points, eg, acute myocardial infarction, coronary revascularization, unstable angina, stroke, transient ischemic attack, and sudden cardiac death. The risk of CV outcomes was lower in ever dispensed testosterone men than in never dispensed men during long-term follow-up.
Higher Hemoglobin in Older Men With Anemia. Testosterone treatment significantly increases hemoglobin levels in older men with low testosterone levels who have unexplained anemia and those who have anemia from known causes, such as iron deficiency. Measurement of testosterone levels is suggested in men aged â¥ 65 years who have unexplained anemia and symptoms of low testosterone levels. No recognized cause can be found in one-third of older men who have anemia.
Treatment Boosts Bone Density, Strength in Older Men. Testosterone treatment of older men who have low testosterone levels significantly increased volumetric trabecular bone mineral density of the lumbar spine and estimated bone strength. Whether testosterone treatment also reduces fracture risk has not been determined.
No Help for Cognitive Function. Testosterone treatment for older men with low testosterone levels and age-associated memory impairment was not significantly associated with improved memory or other cognitive functions. Testosterone was not associated with significant differences in visual memory, executive function, or spatial ability. The findings do not support the use of testosterone for the treatment of age-associated memory decline in older men with symptomatic hypogonadism.
Testosterone Gel Builds Coronary Artery Plaque Volume. In older men who have symptomatic hypogonadism, treatment with testosterone gel was associated with a significantly greater increase in noncalcified coronary artery plaque volume compared with placebo. The clinical significance is not well understood.
Older Men Realize Other Testosterone Benefits. Testosterone treatment that raised testosterone concentrations in symptomatic men aged â¥ 65 years from moderately low to the mid-normal range for men aged 19 to 40 years had the following effects: sexual function, moderate benefit; mood and depressive symptoms, some benefit; vitality and walking distance, no significant benefit. No conclusions were drawn about treatment risks.
Testosterone levels decrease as men age, and the lower testosterone levels in older men may contribute to a variety of symptoms and conditions. Earlier studies of testosterone treatment have produced inconclusive results, but some very recent studies suggest that testosterone treatment for older men with low testosterone levels could have beneficial effects.Scroll through the slides above for the latest findings.Â Find links to studies/abstracts below.Testosterone Lowers Cardiovascular Risks (JAMA Internal Med)Higher Hemoglobin in Older Men with Anemia (JAMA Internal Med) Treatment Boosts Bone Density, Strength in Older Men (JAMA Internal Med)No Help for Cognitive Function (JAMA)Testosterone Gel Builds Coronary Artery Plaque Volume (JAMA)Older Men Realize Other Testosterone Benefits (NEJM)Â