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Gout is associated with a 57% increased risk of ESRD, independent of hypertension and diabetes, according to new research.

Gout: An Independent Risk Factor for Chronic Kidney Disease and Cardiovascular Disease?

A 67-year-old woman noted the appearance of several non-tender, rock-hard, purple-colored nodules on her legs. Her medical history was significant for distant non-Hodgkin lymphoma.

A 67-year-old woman noted the appearance of several non-tender, rock-hard, purple-colored nodules on her legs. Her medical history was significant for distant non-Hodgkin lymphoma. The violaceous color and configuration of the skin lesions suggests which of the following? 

Clinical Topics

Hard Purple Nodules: Your Dx?

Expert dermatologists share practical insights on atopic dermatitis burden, dose flexibility, and pediatric care to support better outcomes in primary care.

Atopic Dermatitis in Focus: 3 Expert Pearls for Primary Care

Atopic dermatitis (AD) is a chronic, relapsing condition with impacts that go well beyond the skin—and primary care clinicians are often the first to assess and manage it. In this short expert video, 3 leading expert dermatologists share practical, real-world insights that can help primary care physicians better support their patients with AD across all life stages.

Watch the video above for insights from Mona Shahriari, MD, on the often-overlooked psychosocial and emotional toll of AD, including mental health burdens, sleep disruption, and what she calls “cumulative life course impairment.” Her message: understanding this hidden burden and asking the right questions during clinic visits can reshape a patient’s long-term quality of life. Also, Raj Chovatiya, MD, shares emerging data on dose flexibility for newer systemic and topical therapies. He explains how patients who achieve disease control may benefit from tailored maintenance regimens, and why primary care clinicians should be aware of these evolving strategies to coordinate care effectively. Finally, Elizabeth Swanson, MD, turns the focus to pediatric care, highlighting anticipated changes in treatment approvals that may expand access for younger children. Her insights offer a preview of what’s coming—and how primary care can prepare.

For other highlights and exclusive expert interviews, check out our full meeting coverage of RAD 2025 here.

RAD 2025: Expert insights on the psychosocial burden of AD, flexible dosing, and cross-specialty collaboration in pediatric care. 

This 13-year-old boy presents with hyperpigmented skin on his neck. He is 66.75 inches and weighs 232 pounds.

This 13-year-old boy presents with hyperpigmented skin on his neck. He is 66.75 inches and weighs 232 pounds. Your suspicion?

13-year-old With Hyperpigmented Rash

A 9-year-old boy presented with a 1-week history of pruritus and rash on his elbows, knees, back, and legs. Several areas of excoriation were noted. He had recently run through a field of tall grass but denied any other exposure history.

A 9-year-old boy presented with a 1-week history of pruritus and rash on his elbows, knees, back, and legs. He had recently run through a field of tall grass but denied any other exposure history. Your Dx?

What Cause of This Itchy Rash?

A 5-year-old boy with a history of atopic dermatitis since 6 weeks of age, presents with a rash around his mouth that has been present for approximately 1 year. The patient’s mother reports that desonide topical cream was applied to the affected area for about 5 days, which initially resulted in improvement, however the rash returned after this medication was discontinued. The rash also recently improved after the patient took amoxicillin for an infection. She also notes that the patient has been licking his lips more frequently.

On examination there is an erythematous papulopustular eruption restricted to the perioral region, with sparing of the vermillion border. Mild hyperpigmentation is noted on the patient’s neck. There is no active involvement of other areas of the body.

The eruption has been present for 1 year and is restricted to the perioral region. What is included in your differential? 

Rash Around the Mouth of a 5-year-old Child

The mother of a 10-year-old boy brings him in for evaluation of his moles (which are all benign). During the visit, the mother asks about the lesions on the first 2 knuckles of his right hand; she initially noticed them several months earlier. The boy is otherwise healthy.

White Knuckles

Chang-fu Kuo, MD

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