Gabapentinoids used Off-label for Pain: Effective or Erroneous?

March 4, 2020

Off-label gabapentin and pregabalin prescribing for pain is widespread; the opioid crisis may be to blame. But does science support the trend? Find out with these 10 questions.

The heightened focus and widening regulatory restrictions on opioid prescribing may be prompting more widespread use of alternatives to this class of medications. Two drugs that are increasingly being prescribed for pain management are the gabapentinoids gabapentin (Neurontin) and pregabalin (Lyrica). There are many questions, however, about their efficacy for the numerous pain conditions for which they are prescribed, off-label. (Contiued below)