• Heart Failure
  • Cardiovascular Clinical Consult
  • Adult Immunization
  • Hepatic Disease
  • Rare Disorders
  • Pediatric Immunization
  • Implementing The Topcon Ocular Telehealth Platform
  • Weight Management
  • Monkeypox
  • Guidelines
  • Men's Health
  • Psychiatry
  • Allergy
  • Nutrition
  • Women's Health
  • Cardiology
  • Substance Use
  • Pediatrics
  • Kidney Disease
  • Genetics
  • Complimentary & Alternative Medicine
  • Dermatology
  • Endocrinology
  • Oral Medicine
  • Otorhinolaryngologic Diseases
  • Pain
  • Gastrointestinal Disorders
  • Geriatrics
  • Infection
  • Musculoskeletal Disorders
  • Obesity
  • Rheumatology
  • Technology
  • Cancer
  • Nephrology
  • Anemia
  • Neurology
  • Pulmonology

How the CLEAR Outcomes Trial Made CV Risk Reduction History, with Lead Investigator Steven Nissen, MD


Bempedoic acid became the first nonstatin LDL-C lowering medication indicated to reduce CV risk in both primary and secondary prevention. Nissen explains how.

Bempedoic acid (Nexletol; Esperion) and bempedoic acid with ezetimibe (Nexlizet; Esperion) were awarded broad new label expansions in March 2024 that include indications for cardiovascular risk reduction and expanded LDL-C lowering in both primary and secondary prevention populations. The label enhancements also support the use of the nonstatin and nonstatin combination either as monotherapy or in combination with statin medications. They are the only LDL-C lowering nonstatin medications indicated for primary CVD prevention.

The significant expansions for CVD risk reduction are based on the US Food and Drug Administration review of data from the pivotal CLEAR Outcomes trial, published in the New England Journal of Medicine. Patient Care spoke with CLEAR Outcomes lead investigator Steven Nissen, MD, and asked him to describe the study, its results, and how the new labeling reflects those findings.

Nissen is Chief Academic Officer, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH and the primary investigator for the bempedoic acid and bempedoic acid plus ezetimibe clinical trial program.

Related Videos
Naomi Fisher, MD, remote blood pressure monitoring
Related Content
© 2024 MJH Life Sciences

All rights reserved.