Squamous Cell Carcinoma In Situ
Eccentric and irregular pigmentation prompted a biopsy in this elderly woman with a history of basal cell carcinoma and melanoma. The surprising diagnosis was a heavily pigmented squamous cell carcinoma in situ.
An 88-year-old woman presented for a periodic total body skin exam. Her history included basal cell carcinoma and melanoma.
Key point: During the exam, an irregularly pigmented lesion was noted on the upper right arm. The lesion was non-tender and non-pruritic. The differential diagnosis primarily revolved around dysplastic nevus and melanoma. However, a biopsy showed heavily pigmented squamous cell carcinoma in situ.
Treatment: The lesion was completely excised.
Note: The actual diagnosis was surprising. Nonetheless, eccentric and irregular pigmentation in a skin lesion should prompt consideration for a biopsy.
Lebrikizumab Demonstrates Efficacy, Safety in Patients With Skin of Color With AD
June 11th 2025RAD 2025. Lebrikizumab improved skin clearance, itch, and pigmentation in patients with skin of color and atopic dermatitis, with strong safety data through 24 weeks, according to late-breaking data.
