Denosumab Superior to Alendronate for Reduction of Postmenopausal Fracture Risk in Real-world Study
Denosumab reduced RR of fracture vs alendronate across fracture types, eg, by 36% for hip fracture, by 43% for nonvertebral fractures, and by 30% for vertebral fractures.
Concussion Patients are Getting Younger: Bad News, Good News
A diagnosis of concussion in an 8-year-old who plays weekend soccer is, on its face, bad news; the good news is that 15 years ago, it might have gone unnoticed, untreated.
USPSTF: Begin Breast Cancer Screening at Age 40 (Not 50) Years for All Women
The lower recommended starting age for screening reflects rising cancer diagnoses among younger women and persistently high mortality rates among Black women.
Women Underrepresented in Late-breaking Cardiovascular Clinical Trials, a New Analysis Finds
Sex-based disparities found in high-profile clinical trials presented at 3 key cardiology scientific meetings underscore the lack of progress made toward equitable inclusion in research.
Start Low, Go Slow with GLP-1 Receptor Agonists when Initiating Weight Management Therapy
GLP-1 RA side effects such as nausea and vomiting can be minimized by starting at the lowest available dose and titrating slowly; Dr Caroline Apovian explains why.
Antiobesity Medications Complement Lifestyle Change in Chronic Weight Management
GLP-1 receptor agonist-based medications for obesity modify gut hormone imbalances, making diet and lifestyle change far more effective, explains Caroline Apovian, MD.
Novel 1-hour Endoscopic Procedure Could Eliminate Need for Insulin in Patients with T2D
The novel ablation technique which "rejuvenates" critical duodenal mucosa, is followed after 2 weeks by treatment with semaglutide and was both safe and effective.
Medicinal Cannabis Effectively Reduced Cancer Pain, Opioid Use in Large Registry Study
Medicinal cannabis products reduced use of opioids and other medications and products that contained balanced measures of THC and CBD appeared most effective.
Friday's 5 Quotes for Primary Care 5-5-2023
Tirzepatide delivers 15.7% weight loss in adults with obesity; remote intervention increases cancer screening in women; women at greater post-MI risk vs men; plus 2 more updates of note.
Early Conversations about Concussions were Hard: AAPM&R Vice President Scott Laker, MD
The vice president of the American Academy of Physical Medicine & Rehabilitation played a significant role in developing early concussion programs and educating clinicians and coaches.
Donanemab Significantly Slows Cognitive, Functional Decline in Early Alzheimer Disease
Eli Lilly's investigational drug targeting amyloid plaque slowed clinical decline by 35% in participants with early symptomatic Alzheimer disease at 18 months, the company announced.
FDA Approves World's First Vaccine Against Respiratory Syncytial Virus
The novel vaccine, from biopharma company GSK, is approved to prevent RSV-associated lower respiratory tract disease in adults aged ≥60 years.
ACP Announces Intensified Advocacy for Equitable Care of Obesity
The American College of Physicians announced an initiative that renews and expands its focus on equitable access to obesity care, including new resources for physicians.
"Eat, Sleep, Console" Reduces Hospital Stay, Medication Use in Opioid-exposed Neonates
Infants with neonatal opioid withdrawal syndrome cared for using a novel functional approach were discharged nearly 7 days sooner than those treated with usual care.
Remote Intervention Increases 3 Cancer Screenings Among Women in Rural US
A combination of outreach measures tailored to the needs of rural Midwest women increased recommended screenings by as much as 6-fold.
Long COVID Diagnosis & Treatment: Many US Physicians Have Doubts
The US health care provider community continues to do its collective best to cope with the protean condition that is long COVID, according to recent poll findings.
Persistent Changes in Brain Function Observed in Persons with Long COVID
Persons with long COVID showed compensatory neural activity in certain brain areas while performing memory tasks as long as 6 months after infection resolved.
Friday's 5 Quotes for Primary Care 4-28-2023
"Disconnect" on anticoagulation between MDs and patients; NASH resolves after bariatric surgery; antiobesity medications are not weight-loss drugs; plus 2 more updates of note.
Tirzepatide Delivers Weight Loss of 15.7% in Adults with Overweight, Obesity
Dubbed the "twincretin," the GLP-1/GIP RA met weight and HgbA1c reduction endpoints, with nearly half of tirzepatide-treated patients achieving weight loss of at least 15%.
Antiobesity Medications Compliment Lifestyle Change in an Optimal Weight Management Plan: Obesity Expert
For persons diagnosed with obesity, a prescription antiobesity medication is just one part of optimal care that includes significant lifestyle change as well, says Caroline Apovian, MD.
The First Antiobesity Medications to Simulate Human Physiology are Indicated for Long-term Treatment
Apovian: GLP-1 receptor agonists are the first antiobesity medications to simulate human physiology, which is why they sustain weight loss and are meant for long-term use.
"Disconnect" on Oral Anticoagulation Observed Between Patients with AF and their Physicians
More than two-thirds of patients not receiving OAC were open to beginning treatment but many of their physicians were not, according to a study of PINNACLE Registry participants.
Metabolic Syndrome and Poor Fitness in Women Increase Long-term CVD Risk: New Research
Women with ischemic heart disease who were metabolically unhealthy but fit were more than 50% more likely to experience a major adverse cardiovascular event.
FDA Clears Omnipod GO Insulin Delivery Device for Persons with Type 2 Diabetes
The wearable tubeless insulin delivery device provides a fixed rate of continuous long-acting insulin for 72 hours, requiring no needles or injections.
Bariatric Surgery Associated with NASH Resolution in Randomized, Open-label Trial
In persons with biopsy-confirmed NASH, the probability of disease resolution was more than 3X greater after RGB or SG vs lifestyle intervention at 52 weeks.
The GLP-1 Receptor Agonist Agents are Antiobesity Medications, Not Weight-loss Drugs
Caroline Apovian, MD, highlights how drugs like semaglutide 2.4 mg treat the chronic relapsing disease of obesity and why a distinction from "weight-loss drugs" is critical.
For Black Women, Breast Cancer Screening Should Begin Almost a Decade Earlier than Current Universal Recommendations
Race- and ethnicity-specific starting ages for screening would help prevent early breast cancer mortality among Black women, according to authors of a new study.
Weight Loss Surgery May Compromise Bone Density and Strength in Adolescents, Young Adults
Significant decreases were observed in bone strength and mean and trabecular BMD 12 months after sleeve gastrectomy in patients aged 13 to 25 years, a new study reveals.
Beverage Choice May Help Reduce Mortality, CVD in Adults with Type 2 Diabetes, Findings Suggest
Higher intake of sugar-sweetened drinks was linked to increased risk of all-cause death and CVD while healthier choices were inversely associated with both, a new study found.
Friday's 5 Quotes for Primary Care 4-21-2023
Statins in AF patients cut risk of TIA; opioid makers must strengthen label warnings; individualized Rx reduces BP; and 2 more research quotes of note.