Butryate Supplementation May Support Pediatric Obesity Treatment
Findings from a new study suggest that supplementing standard care for obesity with butyrate helped reduce BMI, improve glucose metabolism, and reduce inflammation markers.
Influenza Update: Hospital Admissions Double During post-Thanksgiving Week
The inpatient flu census doubled after Thanksgiving travel and gatherings and ICU beds are full. More at-a-glance stats on Flu in the USA, here.
10 More Can't Miss Doctor Gifts Worth Giving for 2022
What about an MDF stethoscope from the wild-animal "Uncaged" collection with snow leopard tubing or a text highlighter that talks back. Find those and 8 more Can't Miss Doctor Gifts.
Tripledemic Virus Spread Could Jeopardize Holiday Season 2022, says CDC Director Walensky
Flu rates are up after the Thanksgiving holiday week, COVID-19 hospitalizations are increasing, and RSV may or may not be on the wane as Christmas approaches.
10 Can't Miss Doctor Gifts Worth Giving (or Having) for 2022-2023
It's time for some good-natured holiday health care gift-giving and we did some window shopping for you. Take a moment, take a breath, and scroll through 10 potential winners.
Statin Prescribing in Primary Care Boosted with EHR Prompts Plus Patient Alerts
An EHR prompt to a physician alone or in combination with a previsit patient prompt both increased statin prescribing in primary care but a patient prompt alone did not.
10 Questions on Holiday Spirits
How does alcohol figure in to American holiday celebrations? We checked with Alcohol.org for this quiz. Are answers what you expect?
Increased Risk of Long COVID Observed in Women, Persons with Elevated BMI
Analysis of an online survey in the UK found women vs men and higher vs lower BMI were associated with greater likelihood of developing long COVID.
First Live Microbiota Treatment for Recurrent CDI Wins FDA Approval
The single-dose biotherapeutic remained effective through 6 months for more than 90% of phased 3 clinical trial participants, according to Ferring Pharmaceuticals.
ASCVD Risk Reduced by 10% with Diet, Greater Drops Seen in Women, Black Adults
The therapeutic impact of the dietary lifestyle intervention and the differential effects could have major implications for clinical care and policy, say study authors.
Decreased Dementia Risk Associated with Increased Daily Step Count
A daily step count of as few as 3800 was associated with a 25% reduced risk of incident dementia in a cohort of 78 000 adults; the optimal count was fewer than 10 000.
Increased Risk of Stroke, CV Event after Herpes Zoster Persists Beyond 12 Years
Study participants who had HZ were at 30% greater sustained risk of stroke and CHD vs those who had not had HZ in this large multicohort prospective study.
US Preterm Birth Rate Reaches 15-year High, Racial Disparities are "Unacceptable"
Racial disparities in maternal, prenatal, and infant care are "stark and unacceptable," say authors of the March of Dimes 2022 Report Card.
Parent-Pediatrician Vaccine Discussions are Lagging, National Poll Finds
One in 7 parents have not discussed vaccines with their child's primary clinician during the 2-year pandemic period, according to a CS Mott Children's Hospital poll.
Allopurinol May Help Prevent First ACS Event in Patients with Gout
Allopurinol exposures of 100 mg or more than 100 mg were associated with lower odds of first-ever ACS with some differences between sexes, a new study reports.
HDL Cholesterol May Not Universally Predict Risk for CHD, May No Longer be So "Good"
The analysis of a large biracial cohort found low levels of HDL-C linked to increased CHD risk in White but not Black adults and high HDL-C was not protective in either group.
CDC Reports Flu Activity at 10-year High as COVID-19 and RSV Fill Hospital Beds
Overall flu activity is at a 10-year high, according to the CDC's most recent influenza surveillance report, while US hospitals are already overwhelmed.
FDA Approves Teplizumab, First Drug Indicated to Prevent Type 1 Diabetes
Teplizumab, an anti-CD3 monoclonal antibody, delayed the median onset of stage 3 T1D by approximately 2 years compared to placebo in a pivotal clinical trial.
The Promise of Precision Medicine for Obesity: It Should be Simple
Ordering an obesity phenotype should be as simple and routine as ordering an HbA1c or a lipid panel, says obesity expert Andres Acosta, MD, PhD.
As Many as 1 in 3 High-risk Patients with Atrial Fibrillation are Not Prescribed Anticoagulation
The low rate of stroke prevention with oral anticoagulation in patients with atrial fibrillation is cause for significant concern, say investigators.
Obesity Phenotype-targeted Treatment Choice Nearly Doubled Weight Loss in Clinical Trials: Investigator Interview
Obesity physician-scientist Andres Acosta, MD, PhD, reviews findings from recent studies he led that suggest true potential for phenotype-focused weight loss intervention.
US Mental Health Crisis Meets Limited Treatment Capacity: APA Survey Findings
While 60% of US psychologists have no openings for new patients, demand for treatment continues to rise, especially among adolescents and health care workers.
Bariatric Surgery Halves Adverse CVD Events in Patients with NAFLD, Severe Obesity
Bariatric surgery reduced by half the risk of CV events including myocardial infarction, heart failure, and stroke compared to nonsurgical care.
How to Build an Obesity Phenotype Step-by-Step, with Andres Acosta, MD, PhD
Obesity phenotyping uses a battery of validated tests and procedures to determine the root cause of a patient's disease and then match treatment accordingly.
Investigational Fentanyl Vaccine Could Block the Opioid from the Brain
A vaccine against fentanyl could stop the intense euphoria the drug creates and also block dangerous physiologic responses like respiratory depression, a new study suggests.
Obesity Phenotypes Explain What Drives the Disease and How to Target Intervention: Expert Interview
Mayo Clinic's Andres Acosta, MD, PhD, details the 4 biologic obesity phenotypes his team has identified and how their use can change weight loss outcomes.
Dupilumab Pooled Phase 3 Trial Data Broadly Support FDA Approval for EoE
Pooled phase 3 data from LIBERTY-EoE-TREET presented at ACAAI 2022 reinforce May 2022 FDA approval of dupilumab for eosinophilic esophagitis.
Andres Acosta, MD, Discusses the Challenge of Heterogeneity in Response to Obesity Treatment
Acosta, a pioneer in the phenotyping of obesity, says one-third of patients don't respond to treatment and he knows why.
Baxdrostat in Phase 2 Clinical Trial Proves Effective, Safe in Treatment-resistant Hypertension
Baxdrostat shows potential to represent the first new class of antihypertensive agents approved since 2017.
Fully Remote Intervention for Hypertension, Lipids Proves Feasible, Successful in Large, Diverse Health Care Network
The Mass General Brigham clinical intervention and study included 10 000 participants and resulted in significant reductions in SBP/DBP and LDL-C.