IDWeek 2023: Nirsevimab Efficacy Against RSV-LRTI-Associated Hospitalization is Robust Across Infant Subgroups
IDWeek 2023. Nirsevimab efficacy was significant across infant subgroups in preventing hospitalization for RSV-LRTI during a first RSV season.
IDWeek 2023: Social Determinants of RSV Hospitalization in Older Adults
IDWeek 2023: Older adults hospitalized with respiratory syncytial virus were more likely to be women, be immunocompromised, and to have traveled within the prior 2 weeks,
Investigational mRNA CMV Vaccine Ready for Phase 3 Clinical Trial, Based on Results of Phase 2 Safety, Efficacy and Dose-Finding Study
The phase 2 study found that nAB responses against epithelial cell infection were strong after each mRNA-1647 dose and sustained through 12 months.
IDWeek 2023 Late Breaker: Efficacy of Single RSVPreF3 Dose Sustained Over 2 Seasons in High-Risk Older Adults
A phase 3 study found VE from a single shot against RSV-LRTD in adults aged ≥60 years persisted through a second season; revaccination did not increase protection.
Pfizer Maternal RSV Vaccine Could Reduce Infant Clinical Events by Tens of Thousands, Costs by $800 Million
A modeling study projected an annual reduction of nearly 25 000 infant hospitalizations and 46 000 ED encounters following maternal vaccination against RSV.
Coadministration of RSV, Influenza Vaccines is Safe and Effective in Older Adults, Study Finds
Immune response in older adults after receiving both vaccines in the same visit was noninferior to sequential administration and the safety profile was acceptable.
Late-Breaker: COVID-19 mRNA-1273 Booster Most Effective Among Adults Aged 65 and Older During Delta, Omicron Surges
The study findings on enhanced immunity from a third mRNA-1273 dose and specific population benefits will help build effective public health policy, authors say.
Breaking: Novel Live-Attenuated Intranasal COVID-19 Vaccine Yields Significant Humoral, Cellular Immune Response
The intranasal delivery and live attenuated form of CoviLiv may strengthen immune response and vaccine acceptance and uptake in populations and regions where both are low.
In People Living with HIV, Switch from Oral ART to Long-Acting Injectable Significantly Improved Adherence, Persistence
IDWeek 2023: In a large cohort of people living with HIV, those switching from oral ART to long acting CAB+RPV were more than 4x as likely to adhere to the regimen.
Real-World Study Finds Long-Acting Cabotegravir+Rilpivirine Highly Effective in Persons with HIV with Detectable Viral Loads at Treatment Inititiaton
Approved for persons with HIV with undetectable VL, CAB+RPV LA may also be appropriate for those with VL ≥50 copies when the therapy is initiated, according to new findings.
IDWeek 2023: Tripledemic Viruses Under the Microscope
COVID-19, influenza, and RSV will be the topics of a different types of sessions examining the history, new diagnostics, prevention, and future treatments during IDWeek 2023.
IDWeek 2023 Features Leaders Spanning the Specialty's Expertise
IDWeek 2023: Leading physician scientists will headline plenary sessions and named lectureships on topics ranging from antibiotic stewardship to artificial intelligence.
How to Get Shots into Arms this Year: Patience, Persistence, and Don't Take it Personally
AAFP president-elect Steven Furr, MD, offers 3 thoughts on maximizing opportunities this year to give all necessary vaccines.
IDWeek 2023, October 11-15: Preview of Topics and Presentations
IDWeek 2023: Imagine an intriguing hot topic in infectious disease and you'll find a session or 2 where you can learn more and then choose the next topic, rinse, and repeat.
AAFP President-Elect Welcomes the Simplicity of the Seasonal COVID-19 Vaccine
The monovalent, singe-shot COVID-19 vaccine simplifies what used to be a complicated conversation with patients and stocking the vaccine fridge, too, says Steven Furr, MD.
AAFP President-Elect Steven Furr, MD, Talks About Vaccination in Practice vs in Theory
Furr on COVID-19 shot: The expectation that 90% of the US population would take this new vaccine that they'd never heard of was probably not practical.
Moderna Investigational Dual Flu/COVID-19 Vaccine Shows Positive Phase 1/2 Results
The combination was found equally as effective as 2 standard influenza vaccine comparators and as the Moderna Spikevax COVID-19 booster shot.
Use of Maintenance Therapy Suboptimal Before Asthma Exacerbations, New Research Finds
Many patients with moderate-to-severe asthma may not be using inhaled corticosteroids along with rescue medications to avoid serious disease exacerbations.
In Older Adults with T2D, Clinical Decision Support Tool Can Reduce Hypoglycemia
In adults older than age 65 years with T2D, a simple clinical decision support tool plus shared decision making reduced hypoglycemic episodes by half.
FDA Adds New Warnings to Labeling for Ozempic
The addition of ileus as a potential adverse event associated with the GLP-1 mimetic is not the first required for the class by the regulator.
One or More Cardiac, Renal, or Metabolic Conditions Affect 25% of US Adults
The prevalence of cardiac, renal, and metabolic conditions has significantly increased over 20 years and so has the number of US adults who have all 3.
A Pediatric Rehabilitation Physician's View on Poverty as Cause and Consequence of Disability
Amy Houtrow, MD, PhD, MPH, considers the impact of poverty on childhood disability and talks about opportunities to breach barriers to health care access.
Adding 3000 Ordinary Steps/Day Reduced BP in Sedentary Older Adults with Hypertension
An e-health lifestyle walking intervention partially supported by remote coaching led to significant improvement in BP in older adults as well as a desire to keep walking.
Oral vs Transdermal Hormone Therapy after Menopause Linked to Increased Risk of NAFLD
Among postmenopausal women taking hormones orally, the NAFLD prevalence increased from 25.3 to 29.4% while it decreased from 24 to 17.3% in those using the transdermal route.
GLP-1 Mimetics, SGLT-2 Inhibitors Understudied in Black Populations in Pivotal Trials, Benefits Questioned
Pivotal cardiovascular outcome trials that evaluated cardiorenal benefits of the newer classes were not designed to consider racial/ethnic variations, researchers state.
Biosimilar Liraglutide Noninferior to Reference Product in Persons with Type 2 Diabetes: Phase 3 Trial
The biosimilar to the GLP-1 mimetic Victoza proved noninferior for reduction of HbA1c and had similar positive effects on body weight, lipids, and blood pressure.
Waist-to-Hip Ratio More Consistently Associated with Mortality vs BMI: New Research
Waist-to-hip ratio was more powerfully and consistently associated with risk of all-cause mortality than BMI or FMI, but can it replace BMI as a clinical indicator?
Long-COVID Rehabilitation Interventions Improve Symptoms but Research on Safety Still Needed
Meta-analysis: Among persons with symptoms of long COVID, respiratory and exercise training were effective but pooled information on safety was "uncertain, imprecise."
Fatigue Common in Migraine, More Severe in Chronic vs Episodic Disease
Fatigue was positively correlated with frequency, duration, severity and chronicity of migraine episodes and more common among chronic migraineurs, a new study reveals.
USPSTF Publishes Final Guidance on Screening for Hypertensive Disorders of Pregnancy
The USPSTF recommends that BP be checked at all prenatal visits for all pregnant persons and calls for reducing vast inequities in maternal health care.
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