October 1st 2024
Your daily dose of the clinical news you may have missed.
September 18th 2024
EASD 2024: Amycretin was also found to be safe and well tolerated in adults with obesity and without diabetes.
September 16th 2024
September 11th 2024
EASD 2024: New data shows survodutide may be beneficial for persons with obesity and MASH.
September 9th 2024
Once-daily oral TERNS-601 was associated with a significant mean 5% weight reduction after 28 days and had a favorable tolerability profile.
Tirzepatide Reduces Risk for Progression from Prediabetes to T2D: Daily Dose
New Findings Underscore Importance of Mental Health Screening in Adolescents Receiving Obesity Treatment
In a study of adolescents with obesity, symptoms of depression and eating disorders decreased over the course of a 52-week intensive behavioral intervention.
Lilly Makes Tirzepatide Single-Dose Vials Available as Self-Pay Option at 50% Discount
Vials of tirzepatide 2.5 mg and 5 mg will be available with a prescription for the labeled drug through LillyDirect after completing a multistep verification process, the company said.
Effectiveness of Anti-Obesity Drugs for CVD Prevention: A Clinician Discussion
Anila Chadha, MD, talks to Patient Care about how antiobesity medications can aid in reducing CVD risk in patients with obesity.
Tirzepatide Cuts Risk of Progression to T2D by 94% Over 3 Years in Adults with Obesity, Overweight
Results of the 3-year SURMOUNT-1 study reflect the longest trial to date of tirzepatide in adults with overweight/obesity and risk for developing T2D.
Cardiovascular Disease Prevention in Patients with Obesity: An Expert Perspective
Anila Chadha, MD, highlights key preventive strategies to reduce CVD risk in patients with obesity and how to tailor them to address individual patient needs.
Shifting Trends in GLP-1RA Prescriptions: Daily Dose
5 Obesity Drugs Worth Watching: 2024-2025
Incretin analogues, an oral glucose formulation that targets endogenous nutrient-sensing pathways and a cannabinoid receptor 1 antagonist are in the new mix.
Semaglutide Sold Online without Prescription May Put Users at Risk for Fraud, Overdose
Semaglutide bought online without a prescription were unregistered, contaminated, and had levels of product that exceeded labeled amount, according to new data.
Obesity and Type 2 Diabetes: Expert Shares 4 Pillars of Management
Caissa Troutman, MD, discusses how clinicians can tailor management plans to reduce risk of developing T2D in patients with obesity.
Tirzepatide Reduces Risk of Heart Failure Outcomes in Adults with HFpEF and Obesity: Phase 3 SUMMIT Trial
Tirzepatide reduced the risk of severe heart failure outcomes by 38% and drove weight loss of 15.7% in adults with HFpEF and obesity, with and without T2D..
Semaglutide Behind Huge Increase in GLP-RA Prescriptions with Fewer Written for Type 2 Diabetes
The significant rise in new GLP-1 RA prescriptions between 2011 and 2023 saw a doubling in the proportion written for obesity and a decline in those for T2D.
Semaglutide vs Tirzepatide for Weight Loss in Persons with Obesity: Daily Dose
Three Obesity-Related Comorbidities and Management Guidance for Primary Care
Get details on the relationship between obesity and mental health conditions, chronic pain, and hypertension, here.
Weight Gain in Early Adult Life Linked to Adverse Cardiac Function, Structure in Older Age
Adiposity before age 60 to 64 years, beginning as early as age 20 years, was associated with adverse cardiac structure and function not explained by current BMI.
Roche Oral Incretin Mimetic CT-966 Moves to Phase 2 Clinical Development
The oral GLP-1 RA was associated with weight loss of 7.3% in just 4 weeks and is designed with unique properties that will enhance multiple outcomes, Roche said.
Exercise Plus Liraglutide May Preserve Bone Quality during Weight Loss: Daily Dose
GLP-1RAs Reduce Risk of Some Obesity-Related Cancers in Patients with T2D: Daily Dose
Weight Loss with Tirzepatide Significantly Greater than with Semaglutide: New Data
Tirzepatide-treated participants were 3 times more likely than those treated with semaglutide to reach weight loss of 15% or greater, the head-to-head study found.
GLP-1RAs Linked to Decreased Risk of Some Obesity-Related Cancers in Patients with T2D
GLP-1RAs were associated with a significantly reduced risk of obesity-associated cancers including gallbladder cancer, pancreatic cancer, and meningioma.
Exercise Plus GLP-1 RA May Preserve BMD During Weight Loss, Study Finds
The preserved bone mass observed in participants taking liraglutide and exercising was seen despite weight reduction levels similar to outcomes with semaglutide and tirzepatide.
5 Questions on the ADA 2024 Standards of Care in Diabetes
This quick quiz tests what you know about updates to the 2024 ADA standards of care, which include guidance on antiobesity drugs and managing comorbid chronic disease.
SURMOUNT-OSA: Tirzepatide Improves Sleep Apnea Symptoms, CV Outcomes in Adults with OSA and Obesity
ADA 2024. Adults with OSA and obesity receiving tirzepatide had improvements in sleep apnea severity and systolic blood pressure compared to placebo.
Pemvidutide Preserves Lean Mass With Weight Loss of Nearly 16%: MOMENTUM Phase 2 Trial
ADA 2024. MOMENTUM trial findings presented at the ADA yesterday showed 78.1% of weight loss attributable to loss of fat vs lean mass in adults with overweight or obesity.
USPSTF Recommends Intensive Behavioral Interventions for Children, Teens with High BMI
The grade B recommendation (moderate certainty) targets youth aged 6 years and older with a BMI at or above the 95th percentile for age and sex.
WHO Issues Medical Product Alert for Counterfeit Semaglutide
Three falsified batches of semaglutide (Ozempic) are in circulation, posing risks for ineffective treatment due to incorrect dosing, contamination, and use of unknown ingredients, warned WHO.
ADA 84th Scientific Sessions: 3 Studies Primary Care Clinicians Should Put on Their Radar
Details on tirzepatide for obesity-related obstructive sleep apnea, semaglutide for prevention of major kidney outcomes in patients with T2D and CKD, more.
ADA Standards of Care in Diabetes 2024: A Guideline Topline
For primary care clinicians, this Guideline Topline provides a summary of 2024 ADA Standard of Care updates that may support improved outcomes in your practice.
ADA 84th Scientific Sessions Preview: STEP-HFp-EF Trial Data, Tirzepatide for Obesity-Related OSA, Optimizing Diabetes Care in Primary Care
Find details on optimizing diabetes care in primary care settings, benefits of GLP-1RAs for patients with HF and diabetes, and tirzepatide use for obesity-related OSA.
Tirzepatide Superior to Placebo in MASH Resolution, Fibrosis Improvement: Daily Dose