Stroke

ENDO 2023: Treatment with bempedoic acid was found comparable to statin therapy in an analysis of the CLEAR Outcomes trial based on CTT Collaboration methodology.

Proposed indications for the investigational factor XIa inhibitor are: stroke prevention after acute ischemic stroke or high-risk transient ischemic attack; recent acute coronary syndrome; and atrial fibrillation.

Bayer's investigational FXIa inhibitor is currently being studied in a large-scale phase 3 development program expected to enroll more than 27 000 participants.

Your daily dose of clinical news you may have missed.

Your daily dose of clinical news you may have missed.

The findings contradict published clinical guidelines that warn against use of estrogen-containing birth control by women who have migraine with aura.

Statin therapy initiated within 1 year of diagnosis of atrial fibrillation reduced the risk of ischemic stroke or systemic embolism by nearly 20%.

Findings also showed that between 1990 and 2019, the global number of ischemic stroke deaths rose from 2 million to 3 million.

Your daily dose of clinical news you may have missed.

More than two-thirds of patients not receiving OAC were open to beginning treatment but many of their physicians were not, according to a study of PINNACLE Registry participants.

Your daily dose of clinical news you may have missed.

EHRA 2023: Patients with AF who started statins within a year of diagnosis had reduced risks of stroke and TIA compared with those who did not start statins.

The rule change would provide flexibility in standards that govern specific ingredients used in food production, permitting replacement of regular sodium with less toxic substitutes.

The magnitude of the association with age did not change, however, for other stroke risk factors, including smoking, atrial fibrillation, and LVH, investigators report.

Researchers found that Black and Hispanic Americans were less likely to be treated for certain poststroke complications, such as mood and spasticity, compared to White adults.

Your daily dose of clinical news you may have missed.

A study of more than 1.5 million women with a history of preeclampsia found up to a 4-fold higher risk of MI and 3-fold increased risk of stroke within 10 years of delivery.

Having both conditions while pregnant in the current study conferred more than double the risk of future CVD vs having either condition alone.

Similar reduction in risk was reported for both lobar and nonlobar intracranial hemorrhage with longer statin treatment associated with greater protection, according to Danish investigators.

Approved in 2020 as Nexletol, bempedoic acid as the first ATP citrate lyase inhibitor and oral non-statin therapy to meet the MACE-4 primary endpoint.

Being most physically active in the late morning had a 16% decreased risk of coronary artery disease and a 17% decreased risk of stroke compared to midday.

"Cardiac rehabilitation is for life," says the NYU Langone Rusk Rehabilitation medical director of cardiac/pulmonary rehab, and he advocates empathy and compassionate understanding.

Study participants who had HZ were at 30% greater sustained risk of stroke and CHD vs those who had not had HZ in this large multicohort prospective study.

Your daily dose of clinical news you may have missed.

Study authors saw a positive dose-response relationship driven by hemorrhagic stroke in young adults who were moderate-to-heavy drinkers in their 20s and 30s.

Apixaban was associated with up to a 28% lower risk of GI bleeding vs the 3 other direct oral anticoagulants in the first large-scale comparative analysis.

Black patients were also at significantly increased risk of stroke, bleeding, and mortality vs White patients 1 year following discharge.

In the absence of randomized controlled head-to-head trials comparing the 2 anticoagulants, study authors say clinicians should consider their findings when choosing treatment.

A T2D diagnosis in adults aged 50 to 59 years vs 60 to 69 years or ≥70 years was linked to significantly increased risk for cardio- and cerebrovascular disease and all-cause mortality.

Only 1 lot of each medication was affected by the mislabeling, according to generic repackaging and distribution services company Golden State Medical Supply.