In this episode, "VMS and Cardiovascular Risk: Mechanisms, Risk Factors, and Prevention," the experts explore the underlying mechanisms that connect vasomotor symptoms to increased cardiovascular risk and discuss how clinicians across specialties can better identify and address that risk.
Dr. Erin Michos outlines several proposed pathophysiological pathways linking VMS to cardiovascular disease. Women with more severe VMS tend to present with worse cardiometabolic profiles, including elevated blood pressure, insulin resistance, adverse lipid levels, and metabolic syndrome. VMS are also discussed as potential markers of endothelial dysfunction, evidenced by reduced flow-mediated dilation, as well as autonomic nervous system dysregulation — characterized by increased sympathetic and decreased parasympathetic tone. Additionally, HPA axis dysregulation, reflected in blunted morning cortisol and elevated urinary cortisol, may further explain the cardiovascular association.