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Cephalosporins are usually considered relatively safe antibiotics; however, serious neurological adverse effects can occur following administration.1-5 Manifestations of cephalosporin-induced neurotoxicity may include confusion, disorientation, twitching, somnolence, myoclonus, and seizures, particularly in patients with reduced renal function.6,7 Here we discuss the mechanism, risk factors, and management of cephalosporin-induced neurotoxicity.

A 92-year-old woman presented with signs and symptoms of heart failure, including marked bilateral lower extremity edema, jugular vein distention, and difficulty in breathing at rest. Her medical history was significant for hyperthyroidism, chronic asthmatic bronchitis, and senile dementia. Medications included oral methimazole, 10 mg/d, and oral theophylline, 200 mg/d.

Podcasts from NIH • Intensive Glucose Control Halves Complications of Longstanding Type 1 Diabetes/Family Risk for Diabetes, Pre-diabetes • NIDDK Resource to Help Guide Diabetic Women Through a Healthy Pregnancy • Older Treatment Is More Effective than New Treatment in Preserving Sight for Some Patients with Diabetes • The Unique Effects of Diabetes on Women

Mental Health Issues in Persons With Diabetes and Related Disorders • Cultural and Ethnic Issues in Psychopharmacology: Addressing Both Instrumental and Symbolic Effects of Treatment • Diabetes May Compromise a Mother’s Mental Health • Examining the Link Between Obesity and Mental Illness 

Consultations and Commentaries • Should Patients With Asymptomatic Celiac Disease Forgo Gluten? • How to Manage Insulin Resistance in Children • Can High-Sugar Foods Be Eaten in a Manner That Supports Health? • If Diabetes Is Multifactorial, Why the Spotlight on Obesity? 

On This Page • Diabetes Q&A • Images in Diabetes • Juvenile Diabetes  • Diabetes and Mental Health • Guidelines and Recommendations • News • Patient Resources • Tools

Glycemic Control and Type 2 Diabetes Mellitus: The Optimal Hemoglobin A1c Targets. A Guidance Statement from the American College of Physicians 

Diabetes is one of the most common and most challenging diseases in primary care. How best to help your patients achieve glycemic control? To that end, we have created this resource page.

To save time and minimize pain and tissue trauma when injecting a joint or soft tissue with a corticosteroid, use a single needle and 2 screw-on syringes. Fill the first syringe with lidocaine and the second with the corticosteroid, then lightly but securely attach the first syringe to the needle. After inserting the needle and achieving local analgesia in the desired location, simply leave the needle in place and, while holding it firmly, switch the syringes; then inject the corticosteroid.

Practical Pointers

During circumcision, a newborn is noted to have continuous dribbling of urine from his meatus and stool from his anus. After several minutes of observation, the urinary stream appears weak and remains a constant trickle. The baby boy was born at term via an uncomplicated spontaneous vaginal delivery. He was treated in the neonatal ICU for hypoglycemia. A radiograph of his pelvis is shown.

Questions from parents touch on almost every aspect of child-rearing and can pose some of the greatest challenges in daily practice. Here, help with some of the thornier questions parents ask.

Specialty formulary management strategies, ePrescribing, and unique formulary benefit designs top the list of critical initiatives at MCOs, according to Cynthia J. Pigg, RPh, MHA, executive director of the Foundation for Managed Care Pharmacy. She discusses results from the Foundation’s 2009 Emerging Trends Survey.

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