Updated Criteria for Inappropriate Medication Use in Elderly Persons
January 1st 2007A consensus panel of experts recently updated the Beerscriteria, one of the most widely used guidelines for medicationuse in older adults.1 Listed in the Table are medicationsthat should generally be avoided in persons aged 65and older-regardless of diagnosis or condition-eitherbecause the agents are ineffective in these patients or becausethey pose unnecessarily high risks.
Cholesterol Lowering and Cancer: A Connection?
January 1st 2007In his "Consultations & Comments" response to a reader’scomments about statins and cancer risk in elderly patients(CONSULTANT, October 2003, page 1389), Dr David Nashnotes that the increased number of deaths from cancer thatoccurred in the second year of the Pravastatin in Elderly Individualsat Risk of Vascular Disease (PROSPER) study canprobably be attributed to disease that was already present beforethe start of the trial.
High HDL-C Plus High LDL-C: To Treat or Not to Treat?
January 1st 2007A number of my patients have very high high-density lipoprotein cholesterol (HDL-C)levels as well as elevated total cholesterol and low-density lipoprotein cholesterol(LDL-C) levels. One such patient is a nonsmoking middle-aged woman whose weightand blood pressure are normal.
Two Cases of Rhythm Disturbance
January 1st 2007For 2 days, a 49-year-old man with hypertension and hypercholesterolemiahas experienced light-headedness and fatigue.Based on the presenting ECG, what is the most likely cause of hissymptoms?A. Accelerated junctional rhythm.B. First-degree atrioventricular (AV) block.C. Mobitz type I (Wenckebach) second-degree AV block.D. Mobitz type II second-degree AV block.E. Third-degree AV block (complete heart block).
Can the Ottawa Ankle Rules Rule Out Arthritis?
January 1st 2007The Ottawa ankle rules are said to help in ruling out ankle fractures and cuttingdown on needless ordering of roentgenograms. How effective are they in differentiatingbetween strain or sprain and inflammatory or noninflammatory arthritis inthe ankle?
Behavioral Symptoms in Alzheimer Dementia:A Guide to Evaluation and Management
January 1st 2007An 81-year-old man presents with severe Alzheimer dementia. Hishistory includes benign prostatic hypertrophy with 2 transurethralresections. He has a remote history of tobacco use and has not used alcohol excessively. He isotherwise in good health. At the time of his original diagnosis, a cholinesterase inhibitor was notprescribed.
Young Man With a History of Vague Headaches Ascribed to Sinusitis
January 1st 2007A 37-year-old man found unresponsiveat home with erratic respiration andurinary incontinence was brought tothe emergency department (ED). Accordingto his family, the patient hadbeen complaining of headaches, vertigo,and mild neck pain for 2 months.During that time, a CT scan of thesinuses revealed chronic sinusitis; thepatient had completed a course ofprednisone, naproxen, and meclizinewithout symptomatic improvement.The day before he was brought to theED, he had presented to a differenthospital with the same complaints andwas given a prescription for antibioticsfor a presumed sinus infection. He haddiet-controlled hypercholesterolemiaand did not smoke.
NSAID Nephrotoxicity Revisited:Selective COX-2 Inhibitors
January 1st 2007For over 25 years, NSAIDs have been used to treat a variety of pain syndromesand inflammatory diseases. More than 50 million Americanstake these drugs. Unfortunately, control of pain and inflammation is notachieved without an associated cost-namely, GI complications and, to a lesserextent, nephrotoxicity.In an attempt to reduce drug-related toxicity, a new class of selectiveNSAIDs-the COX-2 inhibitors-was introduced in 1999. These selectiveNSAIDs are as effective as and pose less risk of gastric toxicity than nonselectiveNSAIDs.1,2The COX-2 inhibitors are thought to reduce end-organ injury, such as GIulceration, by sparing homeostatic or “constitutive” COX-1 enzyme function.1,2 Incontrast, therapeutic effects result from the inhibition of the “inducible” COX-2enzyme.1,2 Such drug effects target the production of proinflammatory prostaglandinsby COX-2 without interrupting normal cell function mediated by COX-1.2,3
Oral Rehydration Therapy for Acute Gastroenteritis in Children: Updated Recommendations From the CDC
January 1st 2007Acute gastroenteritisremains amajor cause ofmorbidity andhospitalizationamong infants and childrenin this country. Every yearin the United States, acutediarrheal illness accountsfor more than 1.5 millionpediatric outpatient visits,200,000 hospitalizations-and approximately 300deaths.