ANN ARBOR, Mich. -- Possible strategies aimed at boosting levels of estradiol and one of its metabolites are being considered to help prevent osteoarthritis of the knee in women approaching menopause, a study here suggested.

RICHMOND, Va. -- When the FDA issues an advisory or recall on an implanted cardioverter-defibrillator (ICD) or pacemaker, physicians must decide whether to replace it immediately or monitor it closely until the scheduled replacement time.

BOSTON -- The increase of obesity in the U.S. has doubled the number of poor-quality radiology reports, labeled "limited by body habitus," over 15 years, researchers reported.

CLEVELAND -- After a real-world multicenter evaluation with varying levels of expertise, the multidetector computed tomography (MDCT) got a thumb's down as a noninvasive competitor for coronary angiography.

INNSBRUCK, Austria -- Impaired olfactory function among chronic alcoholics appears to be associated with prefrontal lobe cognitive dysfunction, researchers here reported.

SACRAMENTO, Calif. -- As a breast cancer preventive agent, tamoxifen has little effect on mortality for most women, according to researchers here.

UTRECHT, The Netherlands -- For men ages 70 to 91, Alzheimer's disease and other dementias have been associated with high levels of endogenous estrogen, but not high levels of testosterone, researchers here reported.

ST. PAUL, Minn. -- The lack of specific neurologic signs predict accurately which patients who are comatose following cardiopulmonary resuscitation will have dismal outcomes, according to fresh American Academy of Neurology guidelines.

ROCHESTER, Minn. -- Although women are more frequently affected with multiple sclerosis, men who have MS are twice as likely to pass it on to their offspring as are women with the disease, researchers have found.

ATLANTA -- Opioid-based prescription painkillers have surpassed cocaine and heroin as the cause of accidental drug overdose deaths in the United States, according to CDC researchers.

ROCKVILLE, Md. -- The FDA issued a warning today to doctors and consumers to avoid the use of an ostensible therapy for Lyme disease called bismacine, also known as chromacine, that may have caused one death and multiple injuries.

WASHINGTON -- Despite President Bush's veto of a bill to relax federal-financing restrictions on embryonic stem cell research, private money keeps the test tubes humming, albeit not at full tilt.

HOUSTON -- Breast cancer survivors can improve their quality of life by incorporating short bouts of exercise into their daily lives, researchers here reported.

BALTIMORE -- When older drivers turn in their car keys, the exchange may be a one-way ticket to institutional living, according to researchers here.

MADRID -- When it comes to therapy for Alzheimer's disease, if a phase II trial isn't all that's expected, try a phase III. So a drug company is moving ahead with studies of the GnRH analog leuprolide.

BOSTON -- Women have risen to considerable prominence since the 1970s as lead authors of research papers in top medical journals, but a clear gender gap remains.

ROCHESTER, N.Y. -- Those pointers that residents get about avoiding the pain of infant circumcision aren't always taken to heart by the attendings who do the teaching.

MADRID, Spain -- An Alzheimer's drug transdermal patch appears to be as effective as capsules and eases compliance worries, researchers said here.

BOSTON -- Two common genetic variants appear to contribute to the development of type 2 diabetes for some patients with impaired glucose tolerance, found researchers here. But lifestyle moves seem to be able to combat the enhanced risk.

BETHESDA, Md. -- A simple blood test for brain natriuretic peptide (BNP) has identified sickle cell patients with pulmonary hypertension, researchers here reported.