HIV AIDS

BETHESDA, Md. -- Two U.S.-led trials of men in sub-Saharan Africa were halted early when interim analyses of results confirmed that circumcision can significantly reduce heterosexual transmission of HIV.

BETHESDA, Md. -- Two U.S.-led trials of men in sub-Saharan Africa were halted early when interim analyses of results confirmed that circumcision can significantly reduce heterosexual transmission of HIV.

A 73-year-old woman presents with apainless, nonpruritic rash of recent onseton her right lower ankle. She has nofever, chills, nausea, vomiting, malaise,or other systemic complaints. Her medicalhistory includes fibromyalgia, osteoarthritis,stable angina, and anxiety;there is no history of connective tissuedisease.

RESEARCH TRIANGLE PARK, N.C. -- Major hormonal contraception methods appear to have little or no effect on HIV susceptibility for women at moderate risk, according to a study of more than 4,000 African women.

ORLANDO -- A novel approach to Burkitt's lymphoma, using a regimen designed for large B-cell lymphomas, led to complete remissions in all patients in a small study, investigators reported here.

SEATTLE -- In a spiral of infection and susceptibility, the African epidemics of HIV and malaria may be fueling each other, according to researchers here. The interplay of the two diseases heightens their effect in regions where both are found.

Primary care physicians' implementation of routine screening is crucial to reducing the incidence of and mortality from HIV. Here's how to implement routine testing in your practice.

NEW HAVEN, Conn. -- All adults in the U.S. should be routinely given a rapid test for HIV unless there's evidence that the local prevalence of undiagnosed infection is less than 0.2%, suggest researchers here.

NEW YORK -- Even while HIV is well controlled in the bloodstream, the gut is suffering a fierce assault on immune cells, according to researchers here. While the attack isn't clinically obvious, it may have long-term effects, especially as people with HIV age.

NEW YORK -- HIV patients should not take drug holidays. That's the unambiguous warning emerging from the randomized Strategies for Management of Antiretroviral Therapy (SMART) study.

ABSTRACT: Painful recurrent ulceration of gingival tissue suggests a secondary intraoral presentation of herpes simplex virus (HSV) infection. Unlike the lesions of HSV, lesions associated with coxsackievirus do not erupt in the anterior mouth but rather on the soft palate and pharynx. Furthermore, unlike HSV infection, coxsackie infections may recur, because there is considerable viral variation. Patients with atrophic or erythematous candidiasis report burning pain and a metallic taste. The typical patient with benign mucous membrane pemphigoid is a woman older than 50 years; the condition usually involves the attached gingiva around the teeth. The lesions of erythema multiforme may erupt on any intraoral mucosa; biopsy may be required to rule out other conditions with similar presentations.

RENNES, France -- HIV can infect immune cells in the testis and produce infectious viral particles that, in turn, can re-infect cells in the blood, according to French researchers.

NIJMEGEN, The Netherlands -- Occupational therapy for patients with dementia and their caregivers improves the ability of both to cope with consequences of the condition, Dutch researchers found.

PHILADELPHIA -- When inhaled corticosteroids don't adequately control a patient's asthma, as often happens, the choice of the next-best add-on therapy is open to debate.

VANCOUVER, British Columbia -- Previous infection with hepatitis C virus and spontaneous clearance of the virus appear to confer protection against re-infection, reported researchers here.

LONDON -- The social forces shaping sexual behaviors among young people worldwide and are strikingly similar, according to a systematic review by a British team.

A 28-year-old man is hospitalized because of highfever with rigors and chills and rapid weight loss(5.4 kg [12 lb] in 2 weeks). During the past 48 hours,generalized throbbing headache, intermittent vomiting,blurry vision, and seizures have developed. The progressiveseizures started in the left hand and have becomegeneralized grand mal.

BOSTON -- Drug-resistant viral strains developed rapidly when exposed to telaprevir, the investigational protease inhibitor against hepatitis C virus (HCV), but both wild-type virus and mutants were controlled by follow-on therapy with interferon and Rebetol.

The NIH’s National Institute of Mental Health is fundinga $60 million effort to find treatments to counteract HIV’seffects on the human brain.

Although it has been evident since the early days of the HIV epidemic that a dementing illness often accompanies HIV infection and that the virus invades the nervous system soon after systemic infection, the clinical syndrome has evolved with the introduction of antiretroviral therapy.

Abstract: Our understanding of the pathobiology of pulmonary arterial hypertension (PAH) has evolved considerably over the past 2 decades, with increasing recognition of the important role that aberrant vasoproliferative responses play in conjunction with disordered vasoconstriction. Classification of the many forms of PAH into categories sharing a similar pathophysiology and clinical presentations help the practicing clinician approach a complex differential diagnosis. Noninvasive tests can be used to narrow this differential but must be applied with an appreciation for their limitations. Transthoracic echocardiography is the screening tool of choice; the workup should also include chest radiography and electrocardiography. However, right heart catheterization is ultimately required to establish the diagnosis. While PAH remains a progressive and generally fatal disease, existing therapies have a significant impact on survival and new therapeutic targets offer great hope for improving the prognosis. (J Respir Dis. 2006;27(11):487-493)

A 38-year-old African American man with HIV infection presents with numerous dyspigmented macules and patches on the extremities, abdomen, and chest; the lesions are smooth, nontender, and minimally pruritic. He has been noncompliant with antiretroviral therapy since his diagnosis 3 years earlier.

A 26-year-old woman with dull left-sided chest pain, nausea, body aches, and low-grade fever is admitted to the hospital. She has been to other emergency departments (EDs) in the area recently with similar complaints and was sent home with diagnoses of anxiety and costochondritis.

Generalized papular, erythematous, nonpruritic, hyperpigmented lesions had appeared on the face, arms (A), chest, and abdomen of a 25-year-old homosexual man with AIDS during the previous month. Anupama Ravi, MD, of Atlanta also noted purple-red, nodular lesions in the right conjunctiva (B) and oral cavity, especially the lower gingiva (C). Other pertinent physical findings included facial edema and hepatosplenomegaly.

A 38-year-old African American man with HIV infection presents with numerous dyspigmented macules and patches on the extremities, abdomen, and chest; the lesions are smooth, nontender, and minimally pruritic.