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Seen here are asymptomatic papillary growths on the gingiva of a 31-year-old homosexual man who is seropositive for HIV. The diagnosis of human papillomavirus (HPV) lesions can be based on appearance and history. Condylomas may also appear flat and smooth or nodular, resembling fibromas. Because cross infection is common, patients who have these lesions-and their partners-are at increased risk for contracting anal and genital condylomas.