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TOKYO -- Diets rich in soy may protect men against localized prostate cancer, but paradoxically may increase the risk for advanced prostate cancer, Japanese researchers reported.

TURIN, Italy -- For patients with newly diagnosed multiple myeloma, a hematopoietic stem-cell autograft followed by an allograft from an HLA-identical sibling outperformed standard bone-marrow ablation and autografts, found investigators here.

SEATTLE -- Obese men diagnosed with prostate cancer in middle age are at a 2.6-fold higher risk of dying from the disease than are patients of normal weight, according to a case-control study.

MANCHESTER, England -- Failures of total hip replacements are significantly more likely to occur when patients carry variants in genes encoding for collagen breakdown and the vitamin D receptor, according to investigators here.

NEW BRUNSWICK, N.J. -- A weekend admission to the hospital with a heart attack is associated with higher death rates and less use of percutaneous coronary interventions, researchers reported.

DURHAM, N.C. -- Even with managed care coverage, patients generally had treatment when visiting a primary care physician's office that met expectations, according to investigators here.

BOSTON -- Supplemental beta carotene over 12 years had no beneficial effect on the occurrence rate of age-related maculopathy, found researchers here.

SPOKANE, Wash. -- Whether anesthesiologists or nurse anesthetists were on the job, there were no significant differences during caesarean births in the rate of anesthetic complications over 12 years, according to investigators here.

CHAPEL Hill, N.C. -- Childbirth and pregnancy complications were responsible for the major part of emergency Medicaid spending for undocumented and recent immigrants in North Carolina, according to a study.

ROCKVILLE, Md. -- The FDA today approved lapatinib (Tykerb), an oral kinase inhibitor that targets HER2-positive tumors, for treatment-refractory metastatic breast cancer, to be used in combination with capectabine (Xeloda).

EXETER, England -- A short walk may help smokers curb tobacco cravings and other withdrawal symptoms, according to a meta-analysis.

SYDNEY, Australia -- The swollen and twisted joints in the hands and feet from rheumatoid arthritis are associated with depression in patients who become unhappy with their physical appearance, researchers here said.

SAN FRANCISCO -- A quarter of all veterans treated at VA hospitals after returning home from the wars in Iraq and Afghanistan brought mental health problems back with them, reported investigators here.

BOSTON -- Beta-amyloid plaques in the brains of those with Alzheimer's type dementia can be spotted with the aid of the imaging agent Pittsburgh Compound B, determined researchers here.

LOS ANGELES -- There is more evidence that sildenafil (Viagra, Revatio) is beneficial to patients with idiopathic pulmonary fibrosis, researchers here reported.

ATLANTA -- Faulty communication between hospital-based and primary care physicians may affect the treatment of nearly one-quarter of patients discharged from the hospital, according to a review of the literature.

ST. PAUL, Minn. -- Epidural steroid injections for lower back pain with sciatica have been given a tepid endorsement in guidelines published by the American Academy of Neurology.

ROCKVILLE, Md. -- The FDA warned today that aggressive use of erythropoiesis-stimulating agents to raise hemoglobin to a target of 12 g/dL or higher was associated with "serious and life-threatening side-effects and or/death."