June 13th 2025
Both oral and subcutaneous formulations of the long-acting GLP-1 and amylin receptor agonist move into stage 3 clinical trials following positive feedback from regulators.
On-Line Program May Avert Eating Disorders in High-Risk Women
August 7th 2006STANFORD, Calif. -- Abnormal body-image concerns and the risk of a full-blown eating disorder in high-risk college-age women can be significantly reduced by an Internet-based behavioral intervention, researchers here reported.
Disadvantaged Elderly Particularly Vulnerable to Heat Wave
August 5th 2006NEW YORK -- The summer is barely half over, and much of the country has had enough-enough of heat-related illness, enough heat-related power outages, and enough heat-related misery from a sweltering wave of extraordinary heat that broke records from coast to coast.
Case In Point: An unusual mediastinal mass
August 1st 2006The authors present a case that demonstrates the diagnostic challenge of mediastinal tumors. They describe the clinical presentation of a patient who had a central endobronchial tumor that was identified as a primary mediastinal spindle cell neoplasm.
Case In Point: Peripheral nerve sheath tumor mimicking pulmonary embolism
August 1st 2006We describe a case in which a patient received thrombolytic therapy after he presented with a clinical picture consistent with submassive pulmonary embolism (PE). Two months later, a malignant peripheral nerve sheath tumor was diagnosed, and the patient died with metastatic disease. The filling defect in the left main pulmonary artery originally interpreted as PE was in fact a tumor. This case describes an unusual presentation of a rare disease (malignant peripheral nerve sheath tumor) mimicking a submassive PE.
Recognizing tracheobronchomalacia
August 1st 2006Abstract: Tracheobronchomalacia is a form of expiratory central airway collapse characterized by softening of the airway wall cartilaginous structures. Symptoms often mimic asthma and chronic obstructive pulmonary disease. Pulmonary function test results may suggest a diagnosis, but findings are neither sensitive nor specific. Bronchoscopy and novel dynamic radiographic studies contribute to the diagnosis and help differentiate true malacia from other forms of expiratory central airway collapse. Treatment options include medication; noninvasive ventilatory support; interventional bronchoscopy with airway stent insertion; and open surgical procedures, such as tracheostomy, tracheal resection, and tracheoplasty. (J Respir Dis. 2006;27(8):327-335)
Lifestyle Can Fend off Type 2 Diabetes Genetic Risk
July 20th 2006BOSTON -- Two common genetic variants appear to contribute to the development of type 2 diabetes for some patients with impaired glucose tolerance, found researchers here. But lifestyle moves seem to be able to combat the enhanced risk.