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PITTSBURGH -- Autism may be a brain-wide phenomenon caused by poor connections among the brain's parts rather than by defects in one or two areas, according to investigators here.

ANN ARBOR, Mich. -- When the cumulative bill for ischemic stroke comes due in 2050 it is likely to total .2 trillion, and that's a conservative estimate, calculated University of Michigan researchers.

SYLMAR, Calif. -- Methicillin-resistant bacteria are taking emergency room doctors back a half-century to the pre-penicillin days, when skin infections were lanced and drained.

ANN ARBOR, Mich. -- About 10% of men with early stage prostate cancer have unnecessary surgery and 45% receive unnecessary radiation, according to researchers here.

TORONTO -- HIV patients are 18 times more likely than the general population to become infected with community-acquired methicillin-resistant Staphylococcus aureus (MRSA), and the rate appears to be increasing.

MADISON, Wis. -- Diets rich in the yellow carotenoids lutein and zeaxanthin may protect against intermediate-stage age-related macular degeneration in healthy women younger than 75.

BOSTON -- There are a lot more chubby babies than there used to be, reported investigators here. That goes for chubby preschoolers, too.

BOSTON -- When it comes to locking away guns in the home, parents of teenagers are likely to loosen the precautions they may have taken when the children were younger, according to researchers here.

CHAPEL HILL, N.C. -- Geneticists are coming to general agreement that they know the future of a breast tumor when they see it.

DURHAM, N.C. -- Using a form of genomic profiling for early non-small-cell lung cancer (NSCLC), researchers here believe they can cherry pick those patients who will benefit most from adjuvant chemotherapy.

ROCHESTER, Minn. -- Botox (botulinum toxin A), that versatile arrow in the plastic surgeon's quiver, appears to help forehead wounds heal with reduced scarring.

ROCHESTER, Minn. -- Variability in a single gene may account for 3% of the worldwide risk for Parkinson's disease, according to an international team.

DALLAS -- For patients with cardiovascular disease, chronic kidney disease is often a fellow traveler, necessitating more sensitive diagnostic tools than serum creatinine alone.

ROCHESTER, Minn. -- An elevated inflammatory response in patients with atopic allergic diseases, especially allergic rhinitis, may predispose them to Parkinson's disease, suggested researchers here.

BOSTON -- Automated external defibrillators, stationed in public places to resuscitate patients in cardiac arrest, had a 20% chance of being recalled for potential malfunction over the past decade, researchers reported.

GAINESVILLE, Fla. -- When it comes to antiepileptic drugs for pregnant women with epilepsy, Depakote (valproate) should be at the bottom of the list, researchers here reported.

NEW HAVEN, Conn. -- Prolonged exposure to ultrasound in the womb causes brain abnormalities in fetal mice -- a finding that raises a cautionary flag about the frivolous use of fetal ultrasound, even though the study is not applicable to humans.

CLEVELAND -- For heart transplant patients, a multidectector spiral CT image could substitute for the annual coronary angiography they need.