Synovitis predates and is associated with the development of radiographic osteoarthritis, new findings suggest. Treating synovitis in knee OA may help reduce disease progression and relieve symptoms. Details here.

The merging of primary psychiatric care with primary medical care is urgently needed. Here’s why.

Here: a gallery of 5 unusual clinical cases and images from our partner Figure 1.

If we had a vaccine that was as effective at reducing HIV infection as circumcision, it would be a recommended vaccine here in the US, argues this pediatrician.

Eruptive xanthomas; smooth-shaped, deeply placed nodules; a solitary itchy patch . . . how much do you know about these and 2 other disorders?

I recently saw a great cartoon. A patient is surrounded by doctors, all turned away from him viewing their respective computer screens. The caption: patient-centered medicine.

Does this rash look like impetigo? Herpes? Tinea? Cellulitis? Here's a close look and a link to the answer and discussion.

Subungual infection; “raccoon eyes;” bed bug bites. . . a quiz to challenge you.

The verdict is in: there’s not enough evidence to support screening of asymptomatic individuals for low vitamin D. Here: a look behind the curtain.

Radiating chest pain and sweating in a middle-aged man who describes a history of anxiety: looks like classic MI, but is it? Watch the video for clues.

These 2 patients presented with a swollen hand and rapidly proximally progressive edema secondary to a bite. What creature did the biting?

A new study suggests that DNA fragmentation and progressive motility may be more accurate and consistent predictors of sperm quality than traditionally measured traits.

Results of a new large study may offer some clarity in an area replete with conflicting findings from small studies in older men or registry studies in special populations.

Current screening and treatment practices are inadequate, according to the lead author of a new study, particularly as fragility fractures among men are projected to increase 3-fold by the year 2050.

This radiograph from a 53-year-old woman revealed esophageal stricture with proximal dilatation in addition to pneumoperitoneum. Pneumatosis cystoides intestinalis (PCI) was diagnosed.

For this young physician in India, reading an article on physician suicide was “the best thing” in his day. There is one thing, he says, that keeps him moving forward.

Bumps on the face; opioids and alcohol; dysmorphic facial features in 6-month-old boy . . . questions on these and other topics in this quiz.

In the avalanche of articles that came across your desk in 2014, were there one or two that struck you as particularly noteworthy? Cast your vote here.

While demonstrating his retro dance moves, a 31-year-old injures his knee doing “the Twist.” Now he can barely walk. Would you order an x-ray?