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August 26th 2025
Patients taking orforglipron achieved significant weight loss, hemoglobin A1c reduction, and cardiometabolic benefits in the phase 3 ATTAIN-2 study, supporting upcoming global regulatory submissions.
Small Left Colon Syndrome in Infants
June 1st 2002Affected infants present shortly afterbirth with a large bowel obstructionsecondary to transient dysmotility inthe descending colon. Although thecause is unknown, immaturity of thecolonic myenteric plexuses has beendemonstrated in some cases. Morethan 50% of affected infants are bornto mothers with diabetes. Other predisposingfactors include hypoglycemiaand sepsis.
Tight Skin in a Patient With Diabetes
May 1st 2002This patient with long-standing insulin-dependent diabetes has difficultyclosing his hand because of “tight skin.” Diabetes is the cause: this findingoccurs more often in persons with microvascular complications, such asretinopathy and nephropathy. The condition may occur even in patients withwell-controlled diabetes.
Diabetic Retinopathy in a 56-Year-OldMan
May 1st 2002Diabetic retinopathy is the most common cause of legal blindness in personsbetween the ages of 20 and 65 years. In this 56-year-old man with a 20-yearhistory of type 2 diabetes, multiple, scattered intraretinal (dot-blot) hemorrhagesand superficial nerve fiber layer (splinter) hemorrhages can be seen.An occasional Roth spot-an intraretinal hemorrhage with a white center thatrepresents a fibrin thrombus which occludes a ruptured blood vessel-is alsoevident. Numerous yellow, waxy, hard exudates are seen between the innerplexiform and inner nuclear layers of the retina. Cotton-wool spots are alsopresent, although no neovascularization is present.
Necrobiosis Lipoidica Diabeticorum
May 1st 2002The atrophic patches on the lower legs of this 47-year-old woman who has haddiabetes mellitus for over 20 years are those of necrobiosis lipoidica diabeticorum.These areas involve degeneration of collagen and elastic fibers in thelower dermis and changes in blood vessel walls. The lesions usually begin assingle or multiple elevated reddish nodules, most commonly in the pretibialarea. Over time, they expand and coalesce into distinctive brownish yellowpatches. These areas may be somewhat tender, but as they spread, theyfrequently become painless-unless they ulcerate. Because the involved skinis fragile, ulcers can form after any minor trauma.
Menstrual Migraine: How "Mini-Prophylaxis" Can Work for Your Patient
May 1st 2002Migraine is an episodic, often debilitatingcondition that affects women moreoften than men. Twenty-eight millionAmericans suffer from migraineheadaches-and nearly 75% of theseare women.1 Unlike other chronic painconditions, migraine has its peakprevalence during the years of greatestproductivity, when most women arejuggling family responsibilities andcareers.2 Many women are particularlysusceptible to migraine attacks justbefore and during menses.
Prednisone for Stevens-Johnson Syndrome
April 15th 2002Levofloxacin, 500 mg/d, had been prescribed for a 74-year-old woman who had a urinary tract infection. The patient had type 2 diabetes and hypertension. She was allergic to sulfa drugs. Two hours after taking the first oral dose of the antibiotic, painful blisters developed on the lower lip and soft palate.
Dyslipidemia: Rational Use of the Statins
January 1st 2002Although the cardiovascular death ratehas declined in the United States, thenumber of hospitalizations for cardiacdisease has not. The improvement incare has been offset by an increase inthe number of older Americans. By2050, more than 100 million Americanswill be 60 years of age or older,and about 30 million will be older than80 years.